It is only a matter of time before SP resistance becomes too high to make the drug sufficiently effective".

After a culture period of about 1000 generations descendants of the original strain were obtained which used 5-chlorouracil as complete substitute for thymine.

Similarly, for infants living in high-transmission areas of Africa, 3 doses of intermittent preventive treatment with SP is recommended delivered alongside routine vaccinations.

A: In most parts of the world, falciparum malaria has become resistant to conventional treatment, such as chloroquine, sulfadoxine-pyrimethamine, and other antimalarial medicines used on their own.

WHO recommends intermittent preventive treatment with sulfadoxine-pyrimethamine for pregnant women living in high transmission areas, during the second and third trimesters.