Of course not; it might be seen as rather sad, if not downright suspect.

Most of you know I opposed this war from the start. I thought it was a tragic mistake.

The turtle tried again and again while a couple of birds sitting on a branch watched his sad efforts.

I can think of a thousand way to end your miserable pathetic life, but why bother?

It is a sad fact that she was pulled into the marriage with that man.