| 1 | Leucovorin may also be used to prevent the side-effects of pyrimethamine. | |
| 2 | It is only a matter of time before SP resistance becomes too high to make the drug sufficiently effective". | |
| 3 | Resistance to earlier generation antimalarial medicines such as chloroquine and sulfadoxine-pyrimethamine is widespread in most malaria-endemic countries. | |
| 4 | After a culture period of about 1000 generations descendants of the original strain were obtained which used 5-chlorouracil as complete substitute for thymine. | |
| 5 | Similarly, for infants living in high-transmission areas of Africa, 3 doses of intermittent preventive treatment with SP is recommended delivered alongside routine vaccinations. |
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